A Proven Anti-Ageing Skincare Range,
Changing The Face…..And The Future Of Beauty

SWEDE SUCCESS™ – The Science Behind The Proof
The SWEDE SUCCESS™ Jabu’she Trial

Background

A key ingredient in three products in the SWEDE SUCCESS™ range – Jabu’she Original Crème, Soft Crème, and Eye Crème – is the formula QAL-100, a potent complex comprising coenzyme Q10, acetyl L carnitine, and alpha lipoic acid. The Original Crème was submitted to Karolinska University Hospital in Stockholm in 2002, for an independent trial supervised by Associate Professor Harry Beitner. The results of the trial were so impressive, that they were published in the prestigious British Journal of Dermatology in 2003*, one of the world’s oldest and most respected medical journals, and a vehicle for the publication of both experimental and clinical ethical research. This was a first for an anti-ageing skin cream.

About Karolinska University Hospital, And

Associate Professor Harry Beitner

Located in Stockholm, Karolinska is one of Europe’s leading university hospitals, and home of the Nobel Prize for Medicine. It is a world famous and highly respected research hospital, with a long history of academic excellence and the advancement of modern medicine. Professor Beitner is Chairman of Dermatology at Karolinska’s esteemed Department of Dermatology and Venereology, and one of Sweden’s leading dermatologists. He has a specialty in how the skin ages, and has spent many years researching the subject.

The Trial

The trial was conducted over a 12-week period, and involved 33 women aged 40 to 75, with a mean age of 54.4 years. It was a randomised, double-blind, placebocontrolled study. All of the subjects had one side of their face treated twice per day with Jabu’she™ Original Crème – or “active” cream – containing QAL-100 (5% alpha lipoic acid, coenzyme Q10, and acetyl L carnitine). The other half of the face was treated with an identical cream – or “placebo” – without the alpha lipoic acid component. Neither the subjects nor the investigators knew which cream was which.

The Evaluation Methods

The trial used four methods of evaluation:

  1. Self observations: what each person in the trial observes of any changes to their skin, whether positive or negative.
  2. A clinical evaluation: where changes to the skin are graded on a scale from zero to plus nine for an improvement, and zero to minus nine if an element worsens.
  3. Photographic: the subjects were photographed before and after the trial by the same scientific photographer, in the same place, and using identical equipment and film to ensure standardisation. Two sets of photographs were evaluated
    independently of each other.
  4. Advanced laser profilometry: a technique which takes a silicone imprint of the skin, in this case periorbital area, and measures the depth of a wrinkle. This was the most objective way of measuring the effectiveness of the product.

The Results

Thirty-two of the women completed the study, according to clinical protocol. Key data
includes:

  • The median improvement on the side of the face treated with the active cream was 51%.
  • The side of the face treated with the active cream also showed photographic evidence of decreased pigmentation, under eye bags, puffiness, and pore size.
  • In the self-assessment by subjects, 78% indicated that the side of the face treated by the active cream showed different degrees of improvement.

Why This Trial Is So Significant

There are four primary reasons why this trial is groundbreaking:

  1. In the world of medicine, the credibility of a drug or medical treatment is measured by three key things: an external, independent clinical trial; published results; and the credibility and reputation of the journal in which the results are published.
  2. The trial was a randomised, double-blind, placebo-controlled study – the “gold standard” method in the medical world often used to evaluate a drug or medical treatment. This type of study has been established over many years as the only accurate way to evaluate a treatment, primarily because it eliminates a number of confounding factors which can affect the results i.e. the placebo effect, observer bias, and selection bias to name a few.
  3. The evaluation methods were comprehensive and thorough, and included advanced laser profilometry technology.
  4. The “active” cream used in the trial was SWEDE SUCCESS™ Jabu’she Original Crème.

* British Journal of Dermatology 2003; 149:841-849.